Most definitely! You can tweak and save at any time even in Bank mode. I edit my patches in Bank mode all the time.

Another nice thing about editing in Bank mode is if you screw up the
preset by over tweaking the knobs before you save the patch just switch to the other preset
in that bank then go back to the original preset and start tweaking
all over again.

Turning on the Catch up feature comes in handy too so you don't instantly change the sound when you turn a knob. You have to find the spot in the knob's rotation where the value is stored in the preset then when you move past that point the sound and value start to change.