Wow! All fantastic ideas! DriveFactor would definitely be cool of it could eliminate a plethora of distortion, fuzz, boost, overdrive pedals but that is a tall order. No modeling pedal I've heard to date can accurately do that without sounding a bit fake. I think it would really need to have some type of real booster-buffer-overdrive in it to really slam the front end of an amp to work effectively along with the patches.
MidiFactor awesome as are all the rest yo mentioned. I'd buy one each!