I found the PF did not sound good in an fx loop or before an overdrive. For me it works best AFTER a OD/distortion pedal and into an amp's guitar input (pre amp). If used pre OD (pedal or amp), the distortion just smears the multiple note lines. My advice is to use pedal OD when you need harmonized runs and use a clean-ish amp setting (doesn't have to be completely clean, juts not heavily OD'd).
