I assume you refer to Vsig V220.127.116.11.
I have no problems at all like the ones you describe; working w/2 monitors here too.
Maybe the module specifier opens somewhere in your displays setup, as a very small window that needs resizing (and maybe relocating on a desired monitor)?
In any case close Vsig and erase the VSIGFILE.ini file in the Windows directory. This should fix everything.
Let me know.