Chad,
I'm running Vsig 2 on Windows 7 (er, 6.1 <wink>) x64 without problems. I set it to run at XP SP3.
I'm using a USB-RS232 adapter with the Prolific 2303 chip in it. Once I found a recent driver package (from SerialGear.com, IIRC), it came right up. Whatever adapter you end up with, just make sure to set the comm spec in Device Manager as well as in Vsig.
~Phil
