There's been a ton of posts here about similar issues, so you might want to search around for those to see if they help.
Without restating a lot of things, there are several problems you could have… bad cable, bad jack on the amp, bad tube(s) in the amp, ground loop between TF and Orange, etc., etc. Try a new cable or try an isolation box between the TF and Orange. Just apply some basic trouble-shooting and you should be able to figure out what's causing the noise and how to fix it.
