Are you talking about his guitar sound during the riff? It sounds like 1/8 note delays in the tempo of the song, maybe with 1/4 note delays in the background as well.
I would start with Factory Preset 1:1 change Delay A to 1/8 note and Delay B to 1/4 note. Tap tempo to the song and adjust the Mix knob and Dly Mix knob to taste.
