drive pedals reacts differently when they are driven by different input signals. pitch based effects change signal drastically in same cases and distortion may sound fluby. it's always better to feed distorted sound into pitch shifter, than pitch shifted sound into drive effects. but it also depends on the results you're after. pitch factor in front of drive effects may work for you, why not…
I believe that from some firmware version all factor pedals had input calibration option. dynamic range (I think you used wrong term here) is same never mind line or instrument mode. it's just input/output impedance matching for specific applications in which pedals will be used.
