So, it may make sense, for some of the Programs, (using Dual Mode) to move them to Path 2 and save as a User Program…
With my H9s, I find that, for harmonies, in most cases, it sounds better if I distort the signal first, then harmonize it. The Octaver is one exception I can think of because it seems to track a clean signal much better than a dirty one. But the other pitch modes seem to do fine with a dirty signal.
And, of course, Reverbs and busy delays will probably sound better on Path 2.