I'm running a Strat > 1/4" cables > pedalboard > Eclipse 1/4" input A > Eclipse 1/4" output A > Fender 65 Deluxe Reverb input 1 with a clean tone. I'm running OS 4.0. I've got my Levels set to In Gain 7.0dB, Out Gain -20dB, Wet/Dry Mix 50%, Analog Level 0.0dB, I/O Mode Mono 1, Master Out 0.0dB. Meter setup is, Source – Analog In.
