I would not recommend it as your "main audio device". You need an audio interface, and preferably one with a good clock. I clock everything off my Apogee AD-16X. I don't use the FW in the H8000. I've had zero problems with my H8000 in the 5yrs I've owned. And I'm still running everything connected to my old Apple PowerMac G4!
For your setup, try looking at Apogee, Metric Halo or Motu audio interfaces. Hope this helps.
