While I believe Eventide does not officially provide support, – either Boot Camp or VMWare used with Windows XP works very well on a Mac in my experience, making it easy to use the routing utility. I have both set up on my machines. I've been using XP on my Mac exclusively for this purpose for several months and must say that it works very well. You'll need a USB converter for the 9 pin serial connector on the H8000 as well. I use this on both a laptop (Macbook Pro) as well as a standard iMac20.
I use Vsig on the Mac's System 10.5.8, along with my DAW software – although I have no expertise at Vsig – it does seem to work well given the little I know about it.