MF & TF algorithms are quite large, owing to a number of reasons required by the actual hardware in the pedals. We left them as they are 'cause the idea was to offer the same exact structures as in the pedals.
So, being big as they are, not all of them can be combined with other algorithms. Some can and you should try to check which "matching pairs" are possible. In the new presets I wrote there are some examples of combinations…and more are possible.